刊名:Journal of Trace Elements in Medicine and Biology
出版年:2017
出版时间:January 2017
年:2017
卷:39
期:Complete
页码:140-146
全文大小:905 K
卷排序:39
文摘
Chronic treatment with NaF promoted insulin resistance and decreased insulin signal. NaF treatment caused changes in bone metabolism markers in ovariectomized (OVX) rats. NaF treatment promoted decreased trabecular bone area of the tibia in OVX rats. NaF treatment promoted increased plasma levels of insulin, OCN and TNF-α in OVX rats. Data suggest the need for caution in the use of NaF for the treatment of osteoporosis.