The IL-17A/IL-17RA axis in pulmonary defence and immunopathology
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- 作者：Nicola Ivan Lorè ; ; lore.nicolaivan@hsr.it" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Alessandra BragonziAuthor Vitae ; Cristina CiganaAuthor Vitae
- 关键词：Interleukin (IL)-17A ; Interleukin (IL)-17 receptor A ; Host defence ; Immunopathology
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：19-27
- 全文大小：1375 K
文摘
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The IL-17A/IL-17RA axis is emerging as a key player in both acute and chronic airway inflammatory phases.
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Several cell types secrete IL-17A, depending on the inflammatory phase and type of insult.
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The IL-17A/IL-17RA axis may modulate host resistance and tolerance mechanisms during airway infectious processes.
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IL-17A/IL-17RA axis may drive the resolution of the inflammatory processes or contribute to their pathologic potentials.