Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus

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• 作者：Harish Bokkasam^a ; ¹ ; Matthias Ernst^b ; ¹ ; ^{matthias.ernst@htwsaar.de" class="auth_mail" title="E-mail the corresponding author} ; Marco Guenther^b ; Christian Wagner^c ; Ulrich F. Schaefer^a ; Claus-Michael Lehr^a ; ^d
• 关键词：Mucus ; Rheology ; Optical tweezer ; Inestine ; Trachea ; Viscoelastic properties
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：20 August 2016
• 年：2016
• 卷：510
• 期：1
• 页码：164-167
• 全文大小：1109 K

文摘

Aim of this study was to investigate the similarities and differences at macro- and microscale in the viscoelastic properties of mucus that covers the epithelia of the intestinal and respiratory tract. Natural mucus was collected from pulmonary and intestinal regions of healthy pigs. Macro-rheological investigations were carried out through conventional plate–plate rheometry. Microrheology was investigated using optical tweezers. Our data revealed significant differences both in macro- and micro-rheological properties between respiratory and intestinal mucus.