Sesquiterpene lactones from Saussurea involucrata

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• 作者：Wan  ; Xiao^a ; Xian  ; Li^a ; Ning  ; Li^a ; Makabili  ; Bolati^b ; Xinjun  ; Wang^b ; Xiaoguang  ; Jia^b ;   ; ; Yuqing  ; Zhao^a ;   ; ^c ;   ; ^{yqzhao2012@163.com}
• 关键词：Saussurea involucrate ; Guaiane-type sesquiterpene lactones ; CD technique ; Anti-inflammatory activities ; Cytotoxic activities
• 刊名：Fitoterapia
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：82
• 期：7
• 页码：983-987
• 全文大小：428 K

文摘

Bioassay-directed separation of the ethyl acetate extract from the aerial parts of Saussurea involucrata (Kar. et Kir. ex Maxim) led to the isolation of three new sesquiterpene lactones sausinlactones A (1), B (2), C (3) and six known ones (4?b xmlns="""">9). The structures were established by spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). CD technique was also employed to determine the absolute configurations of new compounds 1?b xmlns="""">3. The anti-inflammatory activities of compounds 1?b xmlns="""">9 and antitumor activities of new compounds 1?b xmlns="""">3 were tested. The results presented that compounds 5 and 6 were responsible for anti-inflammatory activities, and compounds 1 and 2 showed significant cytotoxic activities against A549 cells.