Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
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- 作者：Esther E. Frö ; hlicha ; esther.froehlich@medunigraz.at" class="auth_mail" title="E-mail the corresponding author ; Aitak Farzia ; Raphaela Mayerhofera ; Florian Reichmanna ; Angela Jačana ; Bernhard Wagnerb ; Erwin Zinserb ; Natalie Bordagc ; Christoph Magnesd ; Eleonore Frö ; hliche ; Karl Kashoferf ; Gregor Gorkiewiczf ; g ; h ; Peter Holzera ; peter.holzer@medunigraz.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANOVA ; analysis of variance ; AUC ; area under the curve ; BDNF ; brain-derived neurotrophic factor ; BM ; Barnes maze ; CCL2 ; chemokine (C-C motif) ligand 2 ; CLDN5 ; claudin 5 ; GF ; germ-free ; GRIN2B ; glutamate receptor ; ionotropic ; NMDA2B (epsilon 2) ; N-methyl-d-aspartate receptor subunit 2B ; HPA ; hypothalamic-pituitary-adrenal ; IFN ; interferon ; IL ; interleukin ; LLOQ ; lower limit of quantification ; LPC ; lysophosphatidylcholine ; NORT ; novel object recognition test ; NPY ; neuropeptide Y ; NPY1R ; neuropepti
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：140-155
- 全文大小：2699 K
文摘
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Antibiotic treatment of adult mice impairs object recognition but not spatial memory.
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Gut microbiota disruption alters the metabolic profiles in colon and plasma.
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The cerebral neuropeptide Y system is severely disturbed in gut dysbiosis.