Significant role for IRF3 in both T cell and APC effector functions during T cell responses

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• 作者：Zacharey Guinn^a ; Anna T. Lampe^a ; Deborah M. Brown^a ; ^b ; Thomas M. Petro^b ; ^c ; ^{tpetro@unmc.edu}
• 关键词：IRF ; Interferon Regulatory Factor ; IFN ; interferon ; GrB ; Granzyme B ; ISG ; Interferon stimulated gene ; DCs ; dendritic cells ; INAM ; IRF3-dependent NK-activating molecule ; Eomes ; Eomesodermin
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：141-149
• 全文大小：1711 K
• 卷排序：310

文摘

IRF3 is required in both T cells and APCs for optimal T cell effector function. IRF3 dependent innate immune factors of APCs are induced during T cell responses. IFN-γ from T cells induces ISG54 in macrophages in an IRF3 dependent manner.