Resistance to PGE₂Inhibition of PWM-Stimulated Lymphocytes from Neoplastic Patients

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• 作者：Nicocia ; Giacomo ; Garipoli ; Claudia ; Venza ; Mario ; Venza ; Isabella ; Sottile ; Antonino ; Pitini ; Vincenzo ; et. al.
• 刊名：Clinical Immunology and Immunopathology
• 出版年：1998
• 出版时间：May, 1998
• 年：1998
• 卷：87
• 期：2
• 页码：115-123
• 全文大小：107 K

文摘

PGE₂treatment of mononuclear cells from patients with different types of neoplasias was unable to decrease either the number of plaque-forming cells or the expression of CD71 and CD25 in PWM-driven cultures. In contrast, in previous studies, PGE₂inhibited these parameters in cultured mononuclear cells from normal volunteers. Surgical treatment of cancer patients did not modify the lymphocyte sensitivity to PGE₂after 1 week, but at 2 and 6 months after therapeutical treatment, the inhibition values of the parameters studied were almost similar or very similar to those of normal lymphocytes. The reduction of PGE₂sensitivity in cancer patients was related to the increase of PGE₂levels and, probably, to a PGE₂receptor saturation. A restoration of PGE₂-induced inhibition some months after therapy could be due to the decrease in PGE₂levels and to receptor unsaturation.