Low Merlin expression and high Survivin labeling index are indicators for poor prognosis in patients with malignant pleural mesothelioma
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- 作者：Mayura Meeranga ; Karima Bé ; rarda ; Martina Friessa ; Byron K.Y. Bitanihirwea ; 1 ; Alex Soltermannb ; Bart Vrugtb ; Emanuela Felley-Boscoc ; Raphael Buenod ; William G. Richardsd ; Burkhardt Seiferte ; Rolf Stahelc ; Walter Wedera ; Isabelle Opitza ; isabelle.schmitt-opitz@usz.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Merlin ; Hippo pathway ; Survivin ; Malignant pleural mesothelioma ; Multimodality treatment
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：10
- 期：8
- 页码：1255-1265
- 全文大小：1845 K
文摘
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Merlin and the Hippo pathway are prognostic factors for Malignant Pleural Mesothelioma.
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Low cytoplasmic Merlin expression at diagnosis is associated with shorter survival.
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A high nuclear Survivin labeling index is associated with shorter survival.
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The data was confirmed in 2 patient cohorts undergoing different treatment regimens.