Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs

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• 作者：Michael P. Curtis^a ; Valerie Vaillancourt^a ; Richard M. Goodwin^a ; Nathan A.L. Chubb^a ; William Howson^a ; Tom L. McTier^b ; Aleah Pullins^b ; Erich W. Zinser^b ; Patrick F.M. Meeus^b ; Debra J. Woods^b ; Laura Hedges^c ; Tim Stuk^d ; Jeffrey E. Price^d ; Jason D. Koch^d ; Sanjay R. Menon^a ; ^{sanjay.menon@zoetis.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Sarolaner ; Isoxazoline ; Ectoparasiticide ; Oral flea and tick agent
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 April 2016
• 年：2016
• 卷：26
• 期：7
• 页码：1831-1835
• 全文大小：905 K

文摘

Over the last decade, the isoxazoline motif has become the intense focus of crop protection and animal health companies in their search for novel pesticides and ectoparasiticides. Herein we report the discovery of sarolaner, a proprietary, optimized-for-animal health use isoxazoline, for once-a-month oral treatment of flea and tick infestation on dogs.