Synthesis and immunopotentiating activity of novel isoxazoline functionalized coumarins
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- 作者：Tabasum Ismaila ; tabsismail@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Syed Shafib ; Swarn Singha ; Tabasum Sidiqa ; Anamika Khajuriaa ; Abdul Roufa ; Mahipal Yadava ; Varma Saikama ; Parvinder Pal Singha ; Mohammad Sarwar Alamb ; Nasarul Islamc ; Kalicharan Sharmad ; Halmuthur Mahabalarao Sampath Kumare ; hmskumar@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：7-Hydroxycoumarin ; 2-Isoxazoline ; Bis-heterocycles ; Kinetic resolution ; Immunopotentiation
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：90-104
- 全文大小：3114 K
文摘
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Synthesis of isoxazoline functionalized coumarins was attempted.
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A series of 13 novel isoxazoline functionalized coumarins was synthesized.
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The synthesized compounds exhibit excellent immune potentiating activity.
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The activity of 2,4 and 8 is more than that of Levimasole as standard.