Aneuploidies of chromosomes 1, 4, and 6 are not compatible with human embryos' implantation

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• 作者：M. Cristina Magli ; Luca Gianaroli ; Andor Crippa ; Santiago Munn&#xe9 ; Francesca Robles ; Anna P. Ferraretti
• 关键词：Aneuploidy ; FISH ; clinical pregnancy ; delivery rate ; implantation ; abortion
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：94
• 期：6
• 页码：2012-2016
• 全文大小：236 K

文摘

class=""h4"">Objective

To verify whether chromosomes 1, 4, and 6 have a role in determining oocyte viability.

class=""h4"">Design

Retrospective study.

class=""h4"">Setting

Reproductive Medicine Unit, Società Italiana Studi Medicina della Riproduzione, Bologna, Italy.

class=""h4"">Patient(s)

Eighty-five patients with a normal karyotype who had undergone an assisted conception cycle with chromosomal analysis of first polar bodies for chromosomes 13, 15, 16, 18, 21, and 22 (first panel). A clinical pregnancy was obtained in 43 patients, whereas 42 patients were not pregnant.

class=""h4"">Intervention(s)

After conclusion of clinical pregnancies to delivery or abortion, first polar bodies from 85 patients were reanalyzed for chromosomes 1, 4, and 6 (second panel).

class=""h4"">Main Outcome Measure(s)

Aneuploidy frequency, clinical pregnancy outcome.

class=""h4"">Result(s)

The aneuploidy rate contributed by chromosome 1, 4, and 6 to the oocytes that were normal for the first panel was significantly higher in the nonpregnant patients (28 % ) versus the pregnant patients (11 % ), whereas no difference resulted between term pregnancies (11 % ) and abortions (10 % ). This trend was also observed when studying the first polar bodies from the oocytes that originated the transferred embryos. The frequency of aneuploidy for chromosomes 1 and 4 was comparable with that of chromosomes 15, 16, 21, and 22.

class=""h4"">Conclusion(s)

Aneuploidy of chromosomes 1, 4, and 6 seems to be related to failed implantation and not to spontaneous abortions.