The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria
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- 作者：Denis V. Yashin ; Elena A. Romanova ; Olga K. Ivanova ; Lidia P. Sashchenko ; sashchenko@genebiology.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Tag7 ; Hsp70 ; Necroptosis ; TNFR1 ; Mitochondria ; Lysosoma
- 刊名：Biochimie
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：32-36
- 全文大小：578 K
文摘
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Tag7 can bind to sTNFR1, the soluble fragment of the TNFR1 receptor, and inhibit RIP1 dependent necroptosis.
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Tag7-Hsp70 induces necroptosis via lysosomes and mitochondria.
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Calpains are involved in sygnal transduction from RIP1 kinase to lysosomes.