Ampelopsin attenuates lipopolysaccharide-induced inflammatory response through the inhibition of the NF-κB and JAK2/STAT3 signaling pathways in microglia

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• 作者：Leihua Weng^a ; He Zhang^a ; Xiaoxi Li^a ; Hui Zhan^a ; Fan Chen^a ; Lijuan Han^a ; Yun Xu^a ; ^b ; ^{xuyun20042001@aliyun.com} ; Xiang Cao^a ; ^b ; ^{xiangcao1988@163.com}
• 关键词：Ampelopsin· ; microglia· ; neuroinflammation· ; lipopolysaccharide· ; NF-κB· ; JAK2/STAT3
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：1-8
• 全文大小：974 K
• 卷排序：44

文摘

Ampelopsin (Amp) reduces NO and PGE2 production in LPS-induced microglia. Amp inhibits iNOS and COX-2 expression in LPS-induced microglia. Amp inhibits the production of IL-1β, IL-6 and TNF-α in LPS-induced microglia. Amp inhibits inflammation by suppressing NF-κB and JAK2/STAT3 signaling pathways.