In polymorphic genomic regions indels cluster with nucleotide polymorphism: Quantum Genomics

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• 作者：Longman-Jacobsen ; Natalie ; Williamson ; Joseph F. ; Dawkins ; Roger L. ; Gaudieri ; Silvana
• 关键词：Indels ; Single nucleotide polymorphisms (SNP)s ; Polymorphic blocks ; Quantum genomics ; Major Histocompatibility Complex ; DPB ; diffuse panbronchiolitis ; indel ; insertion and deletion ; kb ; kilobase ; Mb ; megabase ; MHC ; Major Histocompatibility Complex ; nt ; nu
• 刊名：Gene
• 出版年：2003
• 出版时间：July 17, 2003
• 年：2003
• 卷：312
• 期：Complete
• 页码：257-261
• 全文大小：621 K

文摘

Previously, we have described polymorphic frozen blocks (PFBs) within the Major Histocompatibility Complex (MHC) as regions of several hundred kilobases characterised by high nucleotide diversity, little or no recombination, duplicated segments, disease susceptibility, and human endogenous retroviruses. The nucleotide diversity profile within these PFBs shows peaks and troughs outside of the Class I genes, reflecting other important genes (or sequences) in the region. Here we show that indel density is also clustered with similar peaks and troughs. In fact, SNPs and indels are co-located within PFBs.