Direct-acting antiviral treatment in adults infected with hepatitis C virus: Reactivation of hepatitis B virus coinfection as a further challenge
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- 作者：Anne De Montea ; Johan Courjonb ; Rodolphe Antyc ; d ; e ; Eric Cuab ; Alissa Naqvib ; Vé ; ronique Mondainb ; Jacqueline Cottalordaa ; Laurence Olliera ; ollier.l@chu-nice.fr" class="auth_mail" title="E-mail the corresponding author ; Valé ; rie Giordanengoa ; e ; f
- 关键词：HCV Direct-Acting Antivirals ; HBV reactivation ; HIV infection ; NS3/4A protease inhibitors ; NS5A inhibitors ; NS5B polymerase inhibitors
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：27-30
- 全文大小：574 K
文摘
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HBV reactivation occurred in HCV/HBV-coinfected persons during DAAs-based treatment.
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It occurred with various class of DAAs and in HCV genotype 1 or 4-infected patients.
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It occurred independently of the type of HBV infection: chronic, occult or resolved.
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HBV replication increased early during the interferon-free anti-HCV treatment.
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Close monitoring of HBV-coinfection may be warranted during any anti-HCV therapy.