Resolution advances in cryo-EM enable application to drug discovery

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• 作者：Sriram Subramaniam¹ ; ^ss1@nih.gov ; Lesley A Earl¹ ; Veronica Falconieri¹ ; Jacqueline LS Milne¹ ; Edward H Egelman²
• 刊名：Current Opinion in Structural Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：41
• 期：Complete
• 页码：194-202
• 全文大小：2805 K
• 卷排序：41

文摘

There is rapid growth in number of structures determined using cryo-EM methods. Single particle cryo-EM can now achieve resolutions better than 2 Å. Drug discovery applications are emerging and look promising. Improved measures are needed for assessing map resolution for dynamic complexes.