Mechanistic study of intertypic nucleoprotein complex formation and its inhibitory effect toward influenza A virus
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- 作者：Jaraspim Narkpuka ; 1 ; Peera Jaru-Ampornpana ; 1 ; peera.jar@biotec.or.th" class="auth_mail" title="E-mail the corresponding author ; Theressa Subalib ; Fatima Carla T. Bertulfoc ; Phonphimon Wongthidaa ; Anan Jongkaewwattanaa ; anan.jon@biotec.or.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intertypic interference ; Influenza virus ; Nucleoprotein
- 刊名：Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：485
- 期：Complete
- 页码：104-115
- 全文大小：4576 K
文摘
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Polymerase inhibitory effect of BNP is correlated with its binding to ANP.
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Tail loops and receptors of both NPs are critical for intertypic NP binding.
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Phosphorylation of BNP does not abolish intertypic NP binding.
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NP blocks ANP壮s interaction with the PB2 polymerase subunit.
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BNP壮s antiviral effect is specific to influenza A viruses.