Diversity of the CD4 T Cell Alloresponse: The Short and the Long of It
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- 作者：Jason M. Ali1 ; Margaret C. Negus1 ; Thomas M. Conlon1 ; Ines G. Harper1 ; M. Saeed Qureshi1 ; Reza Motallebzadeh1 ; Richard Willis2 ; Kourosh Saeb-Parsy1 ; Eleanor M. Bolton1 ; J. Andrew Bradley1 ; Gavin J. Pettigrew1 ; gjp25@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 February 2016
- 年：2016
- 卷：14
- 期：5
- 页码：1232-1245
- 全文大小：3300 K
文摘
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Direct-pathway CD4 T cell alloresponses are extremely short lived
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Indirect pathway responses vary markedly according to target alloantigen
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In chronic rejection, MHC class I alloantigen is continually processed and presented
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The kinetics of the alloreactive CD4 T cell response are altered profoundly