Molecular identity of cardiac mitochondrial chloride intracellular channel proteins
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- 作者：Devasena Ponnalagua ; Shubha Gururaja Raoa ; Jason Farbera ; Wenyu Xina ; Ahmed Tafsirul Hussaina ; Kajol Shaha ; Soichi Tandab ; Mark Berrymanc ; John C. Edwardsd ; Harpreet Singha ; Harpreet.singh@drexelmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CLIC ; chloride intracellular channel ; DIDS ; 4 ; 4&prime ; -diisothiocyano-2 ; 2&prime ; -stilbenedisulfonic acid ; ETC ; electron transport chain ; IAA-94 ; R(+)-methylindazone ; R(+)-[(6 ; 7-dichloro-2-cyclopentyl-2 ; 3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)-oxy]acetic acid ; IMAC ; inner membrane anion channel ; IMM ; Inner mitochondrial membrane ; IPC ; ischemic preconditioning ; IR ; Ischemia&ndash ; reperfusion ; MI ; myocardial infarction ; mPTP ; mitochondrial permeability transition pore ; MTS ; mitochondrial targeting s
- 刊名：Mitochondrion
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：27
- 期：Complete
- 页码：6-14
- 全文大小：1574 K
文摘
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CLIC1, CLIC4 and CLIC5 are cardiac proteins.
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CLIC4 localizes to the OMM whereas CLIC5 localizes to the IMM.
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DmCLIC localizes to cardiac mitochondria.
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CLIC5 plays a role in modulating mitochondrial ROS generation.