Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant
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- 作者：Ines G. Harper1 ; 2 ; Jason M. Ali1 ; 2 ; Simon J.F. Harper1 ; Elizabeth Wlodek1 ; Jawaher Alsughayyir1 ; Margaret C. Negus1 ; M. Saeed Qureshi1 ; Reza Motalleb-Zadeh1 ; Kourosh Saeb-Parsy1 ; Eleanor M. Bolton1 ; J. Andrew Bradley1 ; Menna R. Clatworthy1 ; Thomas M. Conlon1 ; Gavin J. Pettigrew1 ; gjp25@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1214-1227
- 全文大小：3167 K
文摘
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Donor CD4 T cells provide cognate, but peptide-degenerate, help to all host B cells
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Antibody specificity is determined by concurrent B cell receptor ligation
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Passenger donor CD4 T cells can therefore augment host alloantibody responses
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Host NK cell allorecognition is critical for preventing this augmentation