Identification of gene expression profiling associated with erlotinib-related skin toxicity in pancreatic adenocarcinoma patients
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- 作者：Octavio Cabaa ; 1 ; ocaba@ujaen.es" class="auth_mail" title="E-mail the corresponding author ; Antonio Irigoyenb ; 1 ; antonioirigoyen@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Cristina Jimenez-Lunac ; crisjilu@ugr.es" class="auth_mail" title="E-mail the corresponding author ; Manuel Benavidesd ; manuel.benavides.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author ; Francisco M. Ortuñ ; oe ; fortuno@ugr.es" class="auth_mail" title="E-mail the corresponding author ; Javier Gallegof ; j.gallegoplazas@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ignacio Rojase ; irojas@ugr.es" class="auth_mail" title="E-mail the corresponding author ; Carmen Guillen-Ponceg ; carmen.guillen@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author ; Carolina Torresh ; ctorres@uic.edu" class="auth_mail" title="E-mail the corresponding author ; Enrique Arandai ; enrique.aranda@imibic.org" class="auth_mail" title="E-mail the corresponding author ; Jose Pradosc ; jcprados@ugr.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pancreatic ductal adenocarcinoma ; Erlotinib ; Skin rash ; Microarray
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：113-116
- 全文大小：222 K
文摘
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Skin rash (SR) is the most characteristic side effect of erlotinib in PDAC patients.
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Erlotinib-induced SR has been associated with a better clinical outcome.
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Gene expression profiling was used to determine who will develop this manifestation.
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7 genes involved in different pathways were downregulated in PDAC patients with SR.
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Our profile correlated with erlotinib-induced SR in PDAC could be used for prognosis.