Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition
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- 作者：Manuel Gutié ; rrez-Aguilara ; Diana L. Douglasa ; Anne K. Gibsonc ; Timothy L. Domeierc ; Jeffery D. Molkentind ; e ; Christopher P. Bainesa ; b ; c ; bainesc@missouri.edu" class="auth_mail
- 关键词：ANT ; adenine nucleotide translocase ; CsA ; cyclosporine-A ; CypD ; cyclophilin D ; DTG ; double transgenic ; GST ; glutathione S-transferase ; MHC ; 伪-myosin heavy chain ; MPT ; mitochondrial permeability transition ; NTG ; non-transgenic ; PDB ; protein data bank ; PiC ; mitochondrial phosphate carrier ; RCR ; respiratory control ratio ; shTG ; cardiac-specific shRNA transgenic ; TG ; transgenic ; tTA ; tet-repressor protein ; VDAC ; voltage dependent anion channel
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：July 2014
- 年：2014
- 卷：72
- 期：Complete
- 页码：316-325
- 全文大小：1493 K
文摘
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The phosphate carrier (PiC) has been implicated as a key component of the MPT pore.
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We found that the PiC could directly bind to the MPT pore component cyclophilin-D.
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Yet mice with cardiac-specific expression of PiC exhibited a normal MPT response.
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Mice with cardiac-specific knockdown of PiC also exhibited a normal MPT response.
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Consequently, the PiC does not appear to be a critical component of the MPT pore.