Prodrugs as self-assembled hydrogels: a new paradigm for biomaterials

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• 作者：Praveen Kumar Vemula ; Nikken Wiradharma ; James A Ankrum ; Oscar R Mir ; a ; George John ; Jeffrey M Karp
• 刊名：Current Opinion in Biotechnology
• 出版年：December, 2013
• 年：2013
• 卷：24
• 期：6
• 页码：1174-1182
• 全文大小：2011 K

文摘

Prodrug-based self-assembled hydrogels represent a new class of active biomaterials that can be harnessed for medical applications, in particular the design of stimuli responsive drug delivery devices. In this approach, a promoiety is chemically conjugated to a known-drug to generate an amphiphilic prodrug that is capable of forming self-assembled hydrogels. Prodrug-based self-assembled hydrogels are advantageous as they alter the solubility of the drug, enhance drug loading, and eliminate the use of harmful excipients. In addition, self-assembled prodrug hydrogels can be designed to undergo controlled drug release or tailored degradation in response to biological cues. Herein we review the development of prodrug-based self-assembled hydrogels as an emerging class of biomaterials that overcome several common limitations encountered in conventional drug delivery.