Year-to-year changes in lung function in individuals with cystic fibrosis

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• 作者：Theodore G. Liou ; Eric P. Elkin ; David J. Pasta ; Joan R. Jacobs ; Michael W. Konstan ; Wayne J. Morgan ; Jeffrey S. Wagener
• 关键词：Cystic fibrosis ; Pulmonary function ; Annual trends
• 刊名：Journal of Cystic Fibrosis
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：9
• 期：4
• 页码：250-256
• 全文大小：549 K

文摘

ss=""h4"">Background

We examined the year-to-year change in FEV<sub>1sub> for individuals and the overall cystic fibrosis population to better understand how individual trends may differ from population trends.

ss=""h4"">Methods

We calculated individual yearly changes using the largest annual FEV<sub>1sub> percent predicted (FEV<sub>1sub> % ) measurement in 20,644 patients (6–45 years old) included in the Epidemiologic Study of Cystic Fibrosis. We calculated yearly population changes using age-specific medians.

ss=""h4"">Results

FEV<sub>1sub> % predicted decreased 1–3 points per year for individuals, with maximal decreases in 14–15 year olds. Population changes agreed with individual changes up to age 15; however after age 30, yearly population change approximated zero while individual FEV<sub>1sub> % predicted decreases were 1–2 points per year.

ss=""h4"">Conclusions

Adolescents have the greatest FEV<sub>1sub> % predicted decreases; however, loss of FEV<sub>1sub> is a persistent risk in 6–45 year old CF patients. Recognizing individual year-to-year changes may improve patient-specific care and may suggest new methods for measuring program quality.