Risk factors for rate of decline in FEV<sub>1sub> in adults with cystic fibrosis

详细信息    查看全文

• 作者：Michael W. Konstan ; Jeffrey S. Wagener ; Donald R. VanDevanter ; David J. Pasta ; Ashley Yegin ; Lawrence Rasouliyan ; Wayne J. Morgan
• 关键词：Cystic fibrosis ; Epidemiology ; FEV1 ; Rate of decline ; Risk factors
• 刊名：Journal of Cystic Fibrosis
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：11
• 期：5
• 页码：405-411
• 全文大小：402 K

文摘

ss=""h4"">Background

Previously we assessed risk factors for FEV<sub>1sub> decline in children and adolescents using the Epidemiologic Study of Cystic Fibrosis (J Pediatr 2007;151:134-139); the current study assessed risk factors in adults.

ss=""h4"">Methods

Risk factors for FEV<sub>1sub> decline over 3-5.5 years for ages 18-24 and ¡Ý 25 years were assessed using mixed-model regression.

ss=""h4"">Results

Mean rates of FEV<sub>1sub> decline ( % predicted/year) were ? 1.92 for ages 18-24y (n = 2793) and ? 1.45 for ages ¡Ý 25y (n = 1368). For the 18-24y group, B. cepacia, pancreatic enzyme use, multidrug-resistant P. aeruginosa, cough, mucoid P. aeruginosa, and female sex predicted greater decline; low baseline FEV<sub>1sub> and sinusitis predicted less decline. For the ¡Ý 25y group, only pancreatic enzyme use predicted greater decline; low baseline FEV<sub>1sub> and sinusitis predicted less decline.

ss=""h4"">Conclusions

Risk factors for FEV<sub>1sub> decline in adults < 25 years are similar to those previously identified in children and adolescents; older adults had few statistically significant risk factors.