Identification of EDIL3 on extracellular vesicles involved in breast cancer cell invasion
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- 作者：Jeong-Eun Leea ; 1 ; Pyong-Gon Moona ; 1 ; Young-Eun Choa ; Young-Bum Kimb ; In-San Kimc ; Hoyong Parkd ; Moon-Chang Baeka ; mcbaek@knu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：EVs ; Extracellular vesicles ; FAK ; Focal adhesion kinase ; MVB ; Multivesicular bodies ; cirEVs ; Circulating extracellular vesicles ; EGF ; Epidermal growth factor ; TEM ; Transmission electron microscope ; NTA ; Nanoparticle tracking analysis ; TEABC ; Triethylammonium bicarbonate ; TEMED ; Tetramethylethylenediamine ; FDR ; False discovery rate ; UPLC ; Ultra performance liquid chromatography ; CM ; Conditioned media ; DLS ; Dynamic light scattering ; EMT ; Epithelial to mesenchymal ; GBM ; Glioblastoma multiforme ; XIC
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：17-28
- 全文大小：1925 K
文摘
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EDIL3 on exosomes promotes breast cancer invasion via integrin-FAK signaling.
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Cancer-derived exosomes are sufficient for acceleration of lung micrometastasis.
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EDIL3 on exosomes provides a biomarker candidate for metastatic breast cancer.