Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population
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- 作者：Xiang Yang Zhanga ; b ; xiang.y.zhang@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author ; Yun-Long Tana ; Da-Chun Chena ; Shu-Ping Tana ; Michelle Z. Maloutab ; Jared D. Bernardc ; Jessica L. Combsc ; Sarai Bhattic ; Michael C. Davisc ; Thomas R. Kostenc ; Jair C. Soaresb
- 关键词：Schizophrenia ; Interleukin ; Cytokines ; Symptom ; Genotype
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：140-147
- 全文大小：488 K
文摘
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772 patients and 775 controls were compared for IL-18 level and its -607A/C polymorphism.
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No significant differences in the allele and genotype frequencies between the patients and controls.
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Increased IL-18 and it polymorphism were associated with the PANSS total and G subscale scores.
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Association of IL-18 with clinical symptoms was present only among patients carrying the C allele.