Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p
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- 作者：Zhiqian Liua ; Xiaoqing Weib ; Aiqun Zhanga ; Chonghui Lia ; Jia Baia ; Jiahong Donga ; JHDonghbp@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HNF1A-AS1 ; miR-30b ; Hepatocellular carcinoma ; Oncogene ; Autophagy
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：1268-1275
- 全文大小：2441 K
文摘
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HNF1A-AS1 is frequently overexpressed in HCC tissues and cell lines.
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HNF1A-AS1 functions as an oncogene and autophagy promoter through sponging hsa-miR-30b-5p.
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miR-30b is frequently under-expressed in HCC tissues and cell lines.
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miR-30b functions as an tumor-suppressor and autophagy inhibitor in HCC cell lines.
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ATG5 is a direct target of miR-30b and thereby a ceRNA for HNF1A-AS1.