MicroRNA-17~92 inhibits colorectal cancer progression by targeting angiogenesis
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- 作者：Huabin Maa ; 1 ; Jin-Shui Panb ; 1 ; j.s.pan76@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Li-Xin Jinb ; Jianfeng Wua ; Yan-Dan Renb ; Pengda Chena ; Changchun Xiaoa ; cxiao@scripps.edu" class="auth_mail" title="E-mail the corresponding author ; Jiahuai Hana ; jhan@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; MiR-17~92 ; TGFBR2 ; HIF1α ; VEGFA
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：376
- 期：2
- 页码：293-302
- 全文大小：3521 K
文摘
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MiR-17~92 suppresses tumor progression in a transgenic mouse model of colorectal cancer.
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MiR-17~92 inhibits tumor angiogenesis in CRC mouse model through suppressing expression of several angiogenesis-inducing genes.
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High expression of miR-17~92 correlates with reduced angiogenesis in male colorectal cancers in human patients.