miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer
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- 作者：Jiong Lina ; 1 ; Yao Lina ; 1 ; Li Fanb ; c ; 1 ; Wei Kuangd ; Liwei Zhenge ; Jiahua Wua ; Peng Shangf ; Qiaofeng Wangg ; Jiali Tana ; jasminenov@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-203 ; Cell death ; Cell proliferation ; Tongue squamous-cancer ; PI3KCA
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：382-387
- 全文大小：1101 K
文摘
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Much lower miR-203 expression in cisplatin resistant Tca8113 cells is discovered.
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Delivery of miR-203 can sensitize the Tca8113 cells to cisplatin induced cell death.
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MiR-203 can downregulate PIK3CA through the 3′UTR.
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The effects of miR-203 on cisplatin sensitivity is mainly through PIK3CA pathway.