Bioconcentration and metabolism of ketoconazole and effects on multi-biomarkers in crucian carp (Carassius auratus)
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- 作者：Jianchao Liu ; Guanghua Lu ; ghlu@hhu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Haohan Yang ; Zhenhua Yan ; Yonghua Wang ; Peifang Wang
- 关键词：Ketoconazole ; Bioconcentration ; Metabolism ; Biomarker
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：145-151
- 全文大小：1252 K
文摘
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The bioconcentration and biodistribution of ketoconazole were measured by LC/MS/MS.
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BCF values were highest in the liver with the range of 9.0–257.2.
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Of seven metabolites examined, N-deacetyl-ketoconazole appears to be dominant metabolite in fish.
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Potential adverse effects are possibly caused by the high ketoconazole concentrations in tissues.