Clinical Utility of Next-Generation Sequencing for Oncogenic Mutations in Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation
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- 作者：Marlise R. Luskin1 ; Martin Carroll1 ; David Lieberman2 ; Jennifer J.D. Morrissette2 ; Jianhua Zhao2 ; Lisa Crisalli1 ; David B. Roth2 ; Selina M. Luger1 ; David L. Porter1 ; Ran Reshef3 ; rr3036@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allogeneic stem cell transplantation ; Acute myeloid leukemia ; Relapse ; Next-generation sequencing
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：22
- 期：11
- 页码：1961-1967
- 全文大小：1410 K
文摘
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TP53, WT1, and FLT3-internal tandem duplication mutations are associated with relapse of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
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DNMT3A(+) FLT3-internal tandem duplication (−) NPM1(−) status confers lower risk of post–allogeneic hematopoietic stem cell transplantation relapse
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Clonal evolution is present in acute myeloid leukemia at time of post–allogeneic hematopoietic stem cell transplantation relapse
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Repeat genetic profiling at relapse may uncover acquired actionable mutations