Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population
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- 作者：Tian Yanga ; 1 ; Hongmei Zengb ; 1 ; hongmeizeng2011@163.com" class="auth_mail" title="E-mail the corresponding author ; Wanqing Chenb ; Rongshou Zhengb ; Yang Zhanga ; Zhexuan Lia ; Jun Qic ; Minjie Wangc ; Tianhui Chend ; Jianlin Loue ; Lingeng Luf ; Tong Zhoua ; Shuyang Daig ; Meng Caig ; Weicheng Youa ; Kaifeng Pana ; pankaifeng2002@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：lncRNA ; long non-coding RNA ; gastric cancer ; GC ; RT-qPCR ; reverse transcription-quantitative polymerase chain reaction ; OR ; odds ratio ; CI ; confidence interval ; SV ; stability value ; AUC ; area under the ROC curve
- 刊名：Cancer Epidemiology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：147-153
- 全文大小：436 K
文摘
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This is the first study investigating the association between serum lncRNAs expression and H. pylori infection status with gastric cancer (GC) risk.
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Significant joint effects between H19/LINC00152 expression and H. pylori infection on risk of GC were found.
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A panel of three factors (H19, LINC00152 and H. pylori infection status) could distinguish GCs from controls.
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Serum H19 and LINC00152 may serve as potential biomarkers for GC, particularly for those with H. pylori infection.