Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren’s syndrome

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• 作者：Mengru Liu¹ ; Xinyu Wu¹ ; Xu Liu ; Jing He ; Yin Su ; Jianping Guo ; ^{jianping.guo@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Zhanguo Li
• 关键词：SLE ; systemic lupus erythematosus ; SS ; Sjö ; gren syndrome ; RA ; rheumatoid arthritis ; ANA ; antinuclear autoantibodies ; RF ; rheumatoid factor ; ACPA ; anti-citrullinated protein antibodies ; DCIR ; dendritic cell immunoreceptor ; CRD ; carbohydrate recognition domain ; ITIM ; immunoreceptor tyrosine-based inhibitory motif ; ACR ; American College of Rheumatology ; SNPs ; single-nucleotide polymorphisms ; CHB ; Chinese Han Beijing ; LD ; linkage disequilibrium ; HWE ; Hardy&ndash ; Weinberg equilibrium ; OR ; odds ra
• 刊名：Human Immunology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：76
• 期：11
• 页码：808-811
• 全文大小：323 K

文摘

Dendritic cell immunoreceptor (DCIR) has previously shown an association with rheumatoid arthritis (RA) in Caucasians and Han Chinese. This study was aimed to further investigate whether DCIR polymorphisms are novel susceptibility factors for other autoimmune diseases, i.e. systemic lupus erythematosus (SLE) and primary Sjogren’s syndrome (SS). A total of 1502 patients with SLE, 476 patients with primary SS, and 1278 non-related healthy controls were enrolled in the study. The single-nucleotide polymorphisms (SNPs) rs2377422 and rs10840759 were genotyped using TaqMan assay. The differences in allelic and genotypic distribution between two groups were assessed using Pearson chi-square test, and logistic regression adjusting for age and sex, respectively. P-value <0.025 was considered statistically significant by Bonferroni correction. The SNP rs2377422 confers an increased susceptibility risk to both SLE (allele model: P = 7.65 × 10⁻⁴, OR 1.20; genotype recessive model: P = 0.012, OR 1.29), and primary SS (allele model: P = 3.74 × 10⁻⁴, OR 1.31; genotype dominant model: P = 1.62 × 10⁻⁴, OR 2.02). There is no association between rs10840759 and SLE or primary SS. In conclusion, DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS.