NS1619 regulates the expression of caveolin-1 protein in a time-dependent manner via ROS/PI3K/PKB/FoxO1 signaling pathway in brain tumor microvascular endothelial cells
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- 作者：Rui-ping Caia ; Yi-xue Xueb ; Jian Huangc ; Jin-hui Wangc ; Jia-hong Wanga ; Song-yan Zhaod ; Ting-ting Guana ; Zhou Zhanga ; zzhouzhang@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan-ting Gua ; yanting-gu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Blood-brain tumor barrier ; NS1619 ; Glioma ; Caveolin-1 ; FoxO1
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：369
- 期：Complete
- 页码：109-118
- 全文大小：1891 K
文摘
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The expression of caveolin-1 was upregulated by NS1619 infusion for 15 min.
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The expression of p-FoxO1 was upregulated by NS1619 infusion for 2 h.
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The inhibition of ROS/PI3K/PKB attenuated the level of of p-FoxO1.
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The inhibition of ROS/PI3K/PKB increased the level of caveolin-1.