Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

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• 作者：Jin-Sung Park¹ ; ² ; ¹⁰ ; Il-Kug Kim¹ ; ¹⁰ ; Sangyeul Han² ; ³ ; ¹⁰ ; Intae Park¹ ; ² ; Chan Kim¹ ; Jeomil Bae² ; Seung Ja Oh³ ; Seungjoo Lee⁴ ; Jeong Hoon Kim⁴ ; Dong-Cheol Woo⁵ ; Yulong He⁶ ; Hellmut G. Augustin⁷ ; Injune Kim¹ ; Doheon Lee⁸ ; ⁹ ; ^{dhlee@kaist.ac.kr} ; Gou Young Koh¹ ; ² ; ¹¹ ; ^{gykoh@kaist.ac.kr}
• 关键词：tumor vasculature ; Tie2 activation ; tumor vessel normalization ; tumor microenvironment ; enhanced drug delivery ; M2-like TAM ; angiopoietin-2
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：12 December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：953-967
• 全文大小：6182 K
• 卷排序：30

文摘

ABTAA-induced Tie2 activation and Ang2 inhibition normalize tumor vasculature Tumor vessel normalization leads to enhanced blood perfusion and drug delivery Tumor vessel normalization lessens hypoxia, acidosis, tumor growth, and metastasis Tie2 activation favorably alters the tumor microenvironment and immune infiltration