Silver-catalyzed one-pot synthesis of benzyl 2-alkynoates under ambient pressure of CO₂ and ligand-free conditions

详细信息    查看全文

• 作者：Fang-Jie Guo^a ; ¹ ; Zhi-Zhi Zhang^b ; ¹ ; Jing-Yun Wang^a ; Jing Sun^a ; ; Xiang-Chen Fang^b ; Ming-Dong Zhou^a ; ^{mingdong.zhou@lnpu.edu.cn}
• 关键词：Silver catalysis ; Benzyl 2-alkynoates ; Carboxylative coupling ; Carbon dioxide
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：16 February 2017
• 年：2017
• 卷：73
• 期：7
• 页码：900-906
• 全文大小：587 K
• 卷排序：73

文摘

The carboxylative coupling of aryl/alkyl terminal alkynes, CO2 and benzyl halides was investigated using silver iodide as the catalyst and Cs2CO3 as the base in CH3CN under ligand-free conditions. This reaction protocol shows a wide substrate scope and high functional group tolerance ability for benzyl halides, in which various functionalized benzyl 2-alkynoates were achieved in good yields. This one-pot, ligand-free and CH3CN mediated reaction proved to be easy to handle and could be facilitated under atmospheric CO2 pressure.