PECL3 nanomicells can provide “core-shell” architecture though self-assemble in aqueous solution which has small size less than 100 nm.

Driven by the “core-shell” structure and the electrostatic interaction, PECL3 nanomicells could efficiently encapsulate P-glycoprotein (P-gp) siRNA and doxorubicin (DOX).

PECL3 nanomicelles could actively and passively target solid tumors via FA-mediate cell uptake and the enhanced permeability and retention effect.

D-PECL3/si micelleplexes could generate synergistic anticancer effects and efficiently re-sensitize DOX-resistant breast cancer cells (MCF-7/ADR) to the anticancer drug DOX through the selective inhibition of P-gp.