Anthropometric factors and ovarian cancer risk in the Malm? Diet and Cancer Study

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• 作者：Jenny  ; Brä ; ndstedt^a ;   ; ^b ;   ; ^{jenny.brandstedt@med.lu.se} ; Bj&ouml ; rn  ; Nodin^a ; Jonas  ; Manjer^b ;   ; ^c ; Karin  ; Jirstr&ouml ; m^a
• 关键词：Anthropometry ; Ovarian cancer risk ; Histological subtype ; Differentiation grade ; Clinical stage
• 刊名：Cancer Epidemiology
• 出版年：2011
• 出版时间：October 2011
• 年：2011
• 卷：35
• 期：5
• 页码：432-437
• 全文大小：187 K

文摘

Objective: To examine the associations of measured anthropometric factors, including general and central adiposity, with epithelial ovarian cancer (EOC) risk in the Malm? Diet and Cancer Study. Methods: In 93 incident EOC cases from a Swedish population-based prospective cohort study, seven anthropometric factors; height, weight, BMI, body fat percentage, waist- and hip circumference, and waist-hip ratio (WHR), were categorized by tertiles of baseline anthropometric measurements and relative risks were calculated using multivariate Cox regression models. Results: A high WHR (<0.77, ?.77 to <0.81, ?.81 cm/cm) was associated with a statistically significantly lower overall risk for EOC (RR 0.60; 0.36?.00; p-trend = 0.04), particularly tumours of differentiation grades 1 and 2 (RR 0.27; 0.09?.81; p-trend = 0.03) and clinical stages 1 and 2 (RR 0.32; 0.10?.97; p-trend = 0.03) and these associations were stronger in postmenopausal women. Neither height, weight, BMI, body fat percentage, waist- or hip circumference were associated with overall risk, nor with risk for different subtypes, differentiation grade or stage. Conclusions: These results demonstrate that a high WHR is associated with a decreased risk of EOC. Other anthropometric factors were not associated with EOC risk.