The multi-targeted kinase inhibitor sorafenib inhibits enterovirus 71 replication by regulating IRES-dependent translation of viral proteins
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- 作者：Meng Gaoa ; 1 ; Hao Duana ; 1 ; Jing Liua ; Hao Zhanga ; Xin Wanga ; Meng Zhua ; Jitao Guoa ; Zhenlong Zhaoa ; Lirong Mengb ; Yihong Penga ; ypeng78@bjmu.edu.cn" class="auth_mail
- 关键词：EV71 ; Sorafenib ; IRES ; Antiviral therapy
- 刊名：Antiviral Research
- 出版年：June 2014
- 年：2014
- 卷：106
- 期：Complete
- 页码：80-85
- 全文大小：1125 K
文摘
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We observed non-toxic concentrations of multi-targeted kinase inhibitor sorafenib clearly impaired virus production.
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Sorafenib markedly inhibited the activity of EV71 IRES, first step of the EV71 genomic RNA replication and translation.
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Sorafenib prevented both EV71-induced CPE and the activation of ERK and p38 related to up-regulation COX-2/PGE2 expression.
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We conclude that sorafenib inhibits EV71 replication by regulating viral IRES-dependent translation.