Haemostasis, blood platelets and coagulation

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• 作者：Louise Jobling ; Lorna Eyre
• 关键词：Blood coagulation ; blood platelets ; endothelium ; haemostasis ; vascular
• 刊名：Anaesthesia & Intensive Care Medicine
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：14
• 期：2
• 页码：51-53
• 全文大小：445 K

文摘

Haemostasis occurs through the sophisticated interplay of a number of physiological processes. Both cellular and molecular mechanisms interact to transform blood from its fluid state to localized clot, once the integrity of a vessel wall is interrupted.

An understanding of these processes is important for the anaesthetist as: (i) pathological thrombus formation and haemorrhage occur in trauma and disease states; (ii) ordered haemostasis is essential for survival; and (iii) manipulation of these processes confers a mortality benefit.