Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
详细信息 查看全文
- 作者：Anne Maassa ; b ; anne.maass@med.ovgu.de" class="auth_mail" title="E-mail the corresponding author ; Sandra Dü ; zelc ; Tanja Brigadskid ; e ; Monique Goerkeb ; f ; Andreas Beckeb ; Uwe Sobierayb ; Katja Neumanna ; b ; Martin Lö ; vdé ; nc ; g ; Ulman Lindenbergerc ; h ; i ; Lars Bä ; ckmang ; Rü ; diger Braun-Dullaeusj ; Dö ; rte Ahrensj ; Hans-Jochen Heinzeb ; e ; k ; l ; Notger G. Mü ; llerb ; Volkmar Lessmannd ; e ; Michael Sendtnerm ; Emrah Dü ; zela ; b ; e ; k ; n ; emrah.duezel@dzne.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Exercise ; Neurotrophic factors ; Hippocampus ; Vascular plasticity ; Aging
- 刊名：NeuroImage
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：142-154
- 全文大小：1033 K
文摘
- bel">•
Exercise-related changes in BDNF, IGF, VEGF and PDGF were measured in older adults
- bel">•
Changes in hippocampal perfusion, volume (via 7 T MRI) and memory were assessed
- bel">•
Fitness-related vascular hippocampal plasticity was not linked to growth factors
- bel">•
Changes in IGF-I, hippocampal volume and memory were linked independent of exercise
- bel">•
Potential reasons for negative findings and methodological shortcomings are discussed