Long-term voluntary running improves diet-induced adiposity in young adult mice
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- 作者：Lin Yan ; Lana C. DeMars ; LuAnn K. Johnson
- 关键词：MCP-1 ; monocyte chemotactic protein&ndash ; 1 ; PAI-1 ; plasminogen activator inhibitor&ndash ; 1 ; PDGF-BB ; platelet-derived growth factor&ndash ; BB ; VEGF ; vascular endothelial growth factor
- 刊名：Nutrition Research
- 出版年：2012
- 出版时间：June, 2012
- 年：2012
- 卷：32
- 期：6
- 页码：458-465
- 全文大小：690 K
文摘
The hypothesis of the present study was that physical activity improves diet-induced obesity in young adult mice. Four-week-old male C57BL/6 mice (n = 15/group) were fed the AIN93G diet or a 45 % high-fat diet ( % kJ) with or without access to in-cage activity wheels for 14 weeks. The high-fat diet increased percentage fat body mass compared to the AIN93G diet (P = .042); running reduced percentage fat body mass (P < .0001) and increased percentage lean body mass (P < .0001) in mice fed either diet. Compared with the AIN93G diet, the high-fat diet increased plasma concentrations of insulin (P < .05) and leptin (P < .05) in sedentary mice and inflammatory cytokines monocyte chemotactic protein-1 (MCP-1) (P < .05) and plasminogen activator inhibitor-1 (P < .05) in both sedentary and running mice. The high-fat diet did not affect angiogenic factors vascular endothelial growth factor and platelet-derived growth factor-BB. Running reduced plasma insulin (P < .05) and MCP-1 (P < .05) and increased platelet-derived growth factor-BB (P < .05) in mice fed the high-fat diet. Running reduced leptin (P < .05) and increased plasma vascular endothelial growth factor (P < .0001) regardless of diet fed. In summary, consumption of the high-fat diet increased adiposity in young adult mice; running reduced adiposity, normalized plasma insulin and leptin, and reduced MCP-1 despite continued consumption of the high-fat diet. These results suggest that voluntary running may reduce diet-induced obesity and proinflammation and that young mice may be a useful model of their human age equivalents in studying moderate physical exercise and obesity and obesity-related diseases.