Process modelling and simulation for continuous pharmaceutical manufacturing of artemisinin
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- 作者：Hikaru G. Jolliffe ; Dimitrios I. Gerogiorgis ; D.Gerogiorgis@ed.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Continuous Pharmaceutical Manufacturing (CPM) ; Green chemistry ; Process design ; Process modelling ; Process simulation ; Artemisinin
- 刊名：Chemical Engineering Research and Design
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：310-325
- 全文大小：2298 K
文摘
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Historical analysis of artemisinin price, production and market demand.
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Novel kinetic data analysis and reactor design for complex organic reactions in flow.
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Systematic evaluation of antisolvents for continuous product separation schemes.
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Ethanol and ethyl acetate emerge as potent candidates for continuous crystallisation.
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Continuous designs generate 66.2% less waste (lower E-factors) than the reference batch case.