Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system
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- 作者：Jonathan C. Guito ; Cé ; sar G. Albariñ ; o ; Ayan K. Chakrabarti ; Jonathan S. Towner ; jit8@cdc.gov
- 关键词：Filoviruses ; Ebolavirus ; Marburgvirus ; Neglected pathogens ; Innate immune response ; Viral immune evasion ; Interferon pathway ; Filoviral interferon antagonists ; Virus-host interactions ; Viral protein function
- 刊名：Virology
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：501
- 期：Complete
- 页码：147-165
- 全文大小：2234 K
- 卷排序：501
文摘
We standardized functional assays of IFN antagonists from all isolated filoviruses. Ravn virus VP35 activity was closer to that of ebolaviruses than to Marburg virus. Taï Forest and Sudan virus VP40 proteins displayed moderate inhibitory activities. VP24 of most ebolaviruses and two VP40 proteins found to block IFN induction. VP24 of human-apathogenic Reston virus exhibited greatly impaired antagonism.