CD22 and Siglec-G in B cell function and tolerance

详细信息    查看全文

• 作者：Jonathan C. Poe ; Thomas F. Tedder
• 关键词：B cells ; TI-2 Ag ; CD22 ; Siglec-G
• 刊名：Trends in Immunology
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：33
• 期：8
• 页码：413-420
• 全文大小：1099 K

文摘

The immune system has evolved into two main arms: the primitive innate arm that is the first line of defense but relatively short-lived and broad acting; and the advanced adaptive arm that generates immunological memory, allowing rapid, specific recall responses. T cell-independent type-2 (TI-2) antigens (Ags) invoke innate immune responses. However, due to its ¡®at the ready¡¯ nature, how the innate arm of the immune system maintains tolerance to potentially abundant host TI-2 Ags remains elusive. Therefore, it is important to define the mechanisms that establish innate immune tolerance. This review highlights recent insights into B cell tolerance to theoretical self TI-2 Ags, and examines how the B cell-restricted sialic acid binding Ig-like lectins (Siglecs), CD22 and Siglec-G, might contribute to this process.