Safety and tolerability of cell culture-derived and egg-derived trivalent influenza vaccines in 3 to <18-year-old children and adolescents at risk of influenza-related complications
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- 作者：Javier Diez-Domingoa ; Maurizio de Martinob ; Jose Garcia-Sicilia Lopezc ; Gian Vincenzo Zuccottid ; Giancarlo Icardie ; Alberto Villanif ; David Moreno-Perezg ; Marí ; a Mé ; ndez Herná ; ndezh ; Javier Á ; lvarez Aldeá ; ni ; Ahmed Abdul Mateenj ; ahmed.abdul_mateen@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Igwebuike Enweonyek ; Richard de Rooijk ; Richa Chandral
- 关键词：Safety ; Cell culture-derived ; Influenza vaccine ; At-risk children
- 刊名：International Journal of Infectious Diseases
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：49
- 期：Complete
- 页码：171-178
- 全文大小：545 K
文摘
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This is the first study to assess the safety of cell-derived vaccine in at-risk children.
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The cell culture-derived (TIVc) and egg-derived (TIV) trivalent influenza vaccines were generally well tolerated in children at risk of influenza.
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The TIVc and TIV had similar safety profiles in children at risk of influenza.
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There were no cases of severe fever or serious adverse events (AEs) with either TIVc or TIV.
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The most common solicited AEs were pain, irritability, and headache.