• 作者：Josep Lluis Carbonell i Esteve^a ; ^{schja@infomed.sld.cu} ; ^{josepcarbon@yahoo.es} ; Orlando Perera Boza^b ; Ana Mar&#237 ; a Riveró ; n Cobo^b ; Jesú ; s Gonzá ; lez^b ; Giuseppe Tomasi^c
• 关键词：Antiprogestá ; genos ; Endometriosis ; Mifepristona
• 刊名：Progresos de Obstetricia y Ginecolog¨ªa
• 出版年：2012
• 出版时间：February, 2012
• 年：2012
• 卷：55
• 期：2
• 页码：51-59
• 全文大小：561 K

Objectives

To evaluate the safety and efficacy of 5 mg and 25 mg doses of mifepristone for the treatment of endometriosis.

Design

Randomized double-blind study.

Setting

Eusebio Hern¨¢ndez Hospital, Havana, Cuba.

Subjects

Twenty-six women laparoscopically diagnosed with endometriosis were included.

Treatment

Group I received one tablet of 25 mg mifepristone daily and group II received one tablet of 5 mg mifepristone daily for 6 months. Laparoscopy and endometrial biopsy were performed before and after treatment.

Variable to evaluate efficacy

Reduction in the intensity of dysmenorrhea measured by a visual analogue scale.

Results

In both groups reductions in the intensity of dysmenorrhea and dyspareunia were highly significant compared with initial values (P <.001). All the women were amenorrheic after 45 days of treatment.

Conclusions

At doses of 5 mg or 25 mg, mifepristone could be an alternative for the treatment of endometriosis.