Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen-thawed embryo transfer in natural cycles

详细信息    查看全文

• 作者：Vivian Chi Yan Lee ; M.B.B.S. ; ^{v200lee@hku.hk" class="auth_mail} ; Raymond Hang Wun Li ; M.B.B.S. ; Joyce Chai ; M.B.B.S. ; Tracy Wing Yee Yeung ; M.B.B.S. ; William Shu Biu Yeung ; Ph.D. ; Pak Chung Ho ; M.D. ; Ernest Hung Yu Ng ; M.D.
• 关键词：Frozen&ndash ; thawed embryo transfer ; natural cycle ; progesterone elevation
• 刊名：Fertility and Sterility
• 出版年：May 2014
• 年：2014
• 卷：101
• 期：5
• 页码：1288-1293
• 全文大小：283 K

文摘

To assess the incidence of P elevation (PE) in natural cycles and evaluate its effect on frozen–thawed embryo transfer cycles performed in natural cycles (FET-NC).

Study Design

Retrospective analysis.

Setting

A tertiary assisted reproductive unit.

Patient(s)

Subfertile woman who did not conceive in their stimulated IVF cycle and underwent the first FET-NC cycle.

Intervention(s)

Achieved serum samples were assayed for P concentrations from the day of LH surge up to 3 days before the surge. The cutoff level of PE was defined as 5 nmol/L.

Main Outcome Measure(s)

Clinical and ongoing pregnancy rates.

Result(s)

The incidence of PE in natural cycles was 173 of 610 (28.4%). There were no significant differences in both clinical and ongoing pregnancy rates (39.0% vs. 37.3% and 32.5% vs. 31.7%) between those with vs. without PE on the day of LH surge. If PE lasted for 2 days or more, there was a significant reduction in the clinical pregnancy rate (39.4% vs. 20.7%). Using multivariate logistic regression, women's age, PE for 2 days or more, and the number of top-quality embryos were the significant factors for clinical pregnancy rates in FET-NC.

Conclusion(s)

The incidence of PE in FET-NC was similar to that in stimulated cycles. Progesterone elevation for 2 days or more before the LH surge impaired the clinical pregnancy rate of FET-NC, whereas PE on the day of LH surge only did not have such an adverse effect.