Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum

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• 作者：Juan He^a ; Li-Yan Peng^a ; Lin Tu^a ; Xing-De Wu^a ; Liao-Bing Dong^a ; Zheng-Hong Pan^b ; Xuan-Qin Chen^c ; Jia Su^a ; Yu Zhao^a ; Gang Xu^a ; Xiao Cheng^a ; Yan Li^a ; Qin-Shi Zhao^a ; ^{qinshizhao@mail.kib.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Viburnum odoratissimum ; Vibsane-type diterpenes ; Vibsanols C&ndash ; H ; Vibsanin X ; Cytotoxicity
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：224-229
• 全文大小：446 K

文摘

Seven new vibsane-type diterpenes, vibsanols C–H (1–6) and vibsanin X (7), together with seven analogues, were isolated from the leaves and twigs of Viburnum odoratissimum. The structures of the new compounds were elucidated by extensive spectroscopic methods. All the new compounds were detected for their cytotoxicity. Compound 1 showed significant cytotoxicity against all the tested cell lines (HL-60, SMMC-7721, A-594, MCF-7, and SW-480), with IC₅₀ values of 3.35, 4.41, 5.18, 11.30, and 3.70 μM, respectively. Compounds 4 and 5 also displayed significant cytotoxicity against hepatocellular carcinoma SMMC-7721 cell line, with IC₅₀ values of 3.69 and 3.52 μM, respectively.